Carcinogenesis, Teratogenesis & Mutagenesis ›› 2002, Vol. 14 ›› Issue (1): 22-024.doi: 10.3969/j.issn.1004-616x.2002.01.007

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STUDY OF GENETIC POLYMORPHISM OF GLUTATHIONE S2TRANSFERASE M1 AMONG THREE SUBPOPULATIONS IN YUNNAN PROVINCE

LIANG Zi-qing1; SONG Zhong-kui1 ; XIA Xiao-ling2 ; HUANG Yun-chao2 ; CHAN Ying; WANG Xu1   

  1. 1. Genetic Section , School of Life Sciences , Yunnan Normal University , Kunming 650092 , China ; 2. Chest Surgical
  • Received:2001-05-08 Revised:2001-07-24 Online:2002-01-30 Published:2002-01-30
  • Contact: LIANG Zi-qing

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Abstract: Purpose : To compare the genetic polymorphism of glutathione S-transferase M1 (GSTM1) locus between the populations in Xuanwei and Fuyuan counties in Qujing city and between Qujing and non-Qujing residents in Yunnan province. Methods : Polymerase chain reaction ( PCR) was employed to justify the genotype of the aim population. Results : No significant difference was found in the GSTM1 genotype frequencies among those three groups ( P > 0. 05) , i . e. , the frequencies of GSTM1 null genotype (0/ 0) were 63. 6 % in Xuanwei residents , 64. 5 % in Fuyuan group and 68. 5 % in non-Qujing group , respectively. Conclusion : Among the normal populations studied , the genetic polymorphism distribution of GSTM1 genes was proved to be homogenous. The result is helpful for further research on the association on lung cancer and xenobiotics detoxification genes.

Key words: GSTM1 gene, genotype polymorphism, normal population, “Yunnan”population

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